Giant Cell Tumour এর ময়নাতদন্ত

Giant cell tumour:

Definition: It is an osteolytic of uncertain origin appears mostly in epiphysis in the long bone.

Other names:

  1. Osteoclastoma
  2. Giant cell sarcoma
  3. Benign giant cell tumor

Because of it’s rarely metastatic character giant cell tumor is a locally malignant tumor because rarely metastasis.

Age of onset: 20-45 years (most common in female, usually 3rd decades of life).

Site of onset: Around knee, proximal humerus, distal radius (most common).

History of trauma present (may be)

Chief complaint:


2. Swelling –

👉Towards one side
👉 Skin over the lesion is shiny
👉 Egg shell cracking sound may be on applying pressure.

At the beginning there’s no changes in joint movement but later joint movement diminished.


  1. X-ray
  2. CT scan
  3. MRI (Magnetic resonance imaging)
  4. Arthroscopy
Investigations for Giant Cell Tumor Diagnosis

Biochemical test:

  1. Serum Calcium
  2. Serum phosphate
  3. Serum alkaline phosphatase
  4. Routine blood test

X-ray findings :

  1. Round/oval osteolytic lesion (epiphyseal, eccentric, expanded size).
  2. The cortex is thin & ballooned.
X Ray Findings in Giant Cell Tumor of Bone

Treatment :

👉 Generally treatment depends on size of tissue bone involvement, staging & grading.

  1. Curettage only (85% recurrent)
  2. Bone curettage with bone graft (40%).
  3. Chemical cauterization + curettage
  4. Curettage + cauterization + bone graft
  5. Curettage + chemical cauterization + Bone Cement
  6. Curettage + cryosurgery with liquid nitrogen + bone graft.
  7. Margin excision + bone graft (36%)
  8. Wide excision + bone graft
  9. Amputation

If pulmonary metastasis occur-

  1. Embolization
  2. Excision

Sazzad mahmud

Monowara Sikder Medical College (2015-16).

Platform Academic / Gazi Abdullah Al Mamun

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