- Zoledronic acid is commonly prescribed medication for osteoporosis. Dose is 5 mg in 100 ml IV over at least 15 min once yearly.
- Zoledronic acid reduce fracture risk reduction in vertebral, non vertebral and hip.
- Renal function (creatinine, CCR) and ECG should be done before receiving Zoledronic acid.
- Patients should be well hydrated and asked to drink 2 glasses water before receiving Zoledronic acid. Pre-existing hypocalcaemia should be corrected.
- Acute phase reaction (Fever, myalgia, flu-like illness) can occur in 30% patients receiving their first dose. Paracetamol given 1-2 hr before reduce likelihood of reaction and can also be given to treat the symptoms.
- Contraindicated in patients with CCR <35 mL/min.
- Osteonecrosis of jaw, atypical femur fracture are rare adverse effects.
Dr. M Saifuddin
MBBS (DMC, K-56)
FCPS (Medicine), MD (Endocrinology)
FACE (USA), FACP (USA)
Assistant professor (Endocrinology)
Dhaka Medical College
Platform Academic / Ariful Islam Neloy